The simplest answer is graveyard hate, with cards like Leyline of the Void, Rest in Peace, and Relic of Progenitus being among the best in the format at fighting Dredge and Surgical Extraction also offering a decent amount of value if you can get the timing right (exiling Narcomoeba or Bloodghast makes it hard for Prized Amalgam to return to the battlefield, while getting rid of Creeping Chill with the "exile" trigger on the stack will fizzle the damage)
While it does change the power and toughness to 1 for the creature you target, you might not be going to win through combat damage anyway depending on your build
(Treat it and anything attached to it as though they dont exist until its controllers next turn.) Counter target activated or triggered ability
If this card were not powerful enough, it initially read, Target player loses next turn. during play testing
It gives all your creatures ward 3, which is pretty amazing, and it also turns one creature into a 7/7 and another into a 1/1 whenever it attacks
